After having missed the Molecomb Stakes at Goodwood due to soft ground, the Wesley Ward-trained daughter of Distorted Humour will bid to put her Queen Mary defeat behind her when tackling six furlongs for the first time in the Group Two.
Madeline won a Listed race at Newbury last time and has been declared by Roger Varian, while Aidan O'Brien will rely upon Actress as he seeks a first triumph in the Lowther.
There is further Irish interest in the form of the Ken Condon-trained Mamba Noire.
Threading, from the yard of Mark Johnston, and the William Haggas-trained Special Purpose will put unbeaten records on the line.
The field is completed by Natural (Richard Hannon), Neola (Mick Channon) and So Hi Society (Archie Watson).