Peter Atkinson's prolific mare has won seven of her 11 starts to date and following successive handicap victories at Doncaster in December, she returned to Town Moor for a Grade Two mares' hurdle.
After moving smoothly into contention, she was unable to wear down hot favourite Maria's Benefit, who justified odds-on favouritism to clinch her fifth win on the bounce.
Irish Roe was nicely clear of the remainder, however, and could now take on the boys in one of the most competitive handicaps of the season on February 10.
North Yorkshire-based Atkinson said: "She ran very well on Saturday and we're very happy with her. I think she was beaten by a very good horse on the day.
"We'll see how she comes out of the race in the next few days. She's in the Betfair Hurdle at Newbury and she might go for that if we're happy with her.
"She's not going to have the chance to run in a handicap off 134 again, or at least not for a while."
Irish Roe is a general 16-1 shot for the Betfair Hurdle.
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