Dan Gun and Dog Of War struck for the Skeltons – while Hughes suffered several near misses as his title rival took his winning tally to 145.
Skelton and Hughes are set to continue trading blows throughout the last week of the season – but with just seven days to go before the finale at Sandown, it is the former who has the clear upper hand, and has shortened to 1-20 favourite with the bookmakers.
Brother Dan has nonetheless warned the title is not a done deal yet, and he is expecting more twists and turns still to come in the battle royal at Ayr, Perth, Sandown and elsewhere over the coming days.
The Warwickshire trainer told Sky Sports Racing: “The worst hope is false hope – you can’t think that it’s over, because it certainly isn’t.
“Brian Hughes is definitely going to have more than five winners between now and the end of the season.
“So it’s going to be hard. There’s no time to take your foot off the gas, no time to dwell and reflect – you’ve got to keep going forward.”
He is, however, very proud of what his brother has achieved so far.
“It’s a great position for Harry to be in,” he added.
“Every jockey walks into the weighing room for the very first time and hopes one day they can be in a position to challenge for champion jockey – and he is in that position.
“It’s been an amazing rollercoaster, and I’ve always thought the final week will have a big say in it – and I think Perth (Wednesday to Friday) is going to have a massive, massive say.
“There’s no time to take in what’s going on. It’s all been flat out, but I hope we can look back on it all when we get to the end, and reflect positively.
“I’m proud of Harry. I drive the car a little bit – Tom Messenger does most of that – and I declare the horses.
“When it comes to being champion jockey, it’s a one-man thing. So he’s got to be proud of himself, and we’re all very proud of him.”
Skelton stretched his title advantage in the opening race, the first division of the Potter Group Handicap Hurdle.
Dan Gun provided him with his 144th winner before noon, on a card which got under way at 11.25 so it could be completed before the funeral of the Duke of Edinburgh.
The 13-8 favourite was delivered from off the pace and was clear at the last, beating Hughes and Rubytwo into second by six and a half lengths.
Both jockeys were unplaced in division two, and then Hughes had to settle for second again in the Maelor Handicap Chase – leading at the last on Discko Des Plages only to be run out of it by Aidan Coleman on another of the 3-1 co-favourites, Casa Tall.
Hughes’ run of near misses continued in a groundhog scenario in the Darlands Novices’ Handicap Chase, with the extra aggravation for him this time of finishing second to Skelton again.
The championship leader arrived with a telling challenge at the last once more as Dog Of War defied a minor market drift to 3-1 to beat Hughes on 2-1 favourite Armattiekan by a length and a half.
The winning jockey said: “He did it really well, and travelled well.
“Since he only ran the other day, we hadn’t done a lot with him – maybe we should have done a bit more, because he was quite fresh.
“I’ll keep rolling, keep going.”
The Skeltons were, however, then out of luck with their last runner of the day – Interconnected in the Horseradish Maiden Hurdle.
In the absence of Hughes, the long odds-on favourite appeared to have a golden opportunity to break his duck but instead fell at the last when upsides the 28-1 winner Aviewtosea.
Both horse and jockey were unscathed.We've teamed up with the Flat experts at Timeform to bring you a FREE copy of their latest book - 50 Flat Horses to Follow throughout the 2021 season. Click here to claim yours for FREE!
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